p53 in 3-D.

p53 in 3-D.

-Since 1975, 191 patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (ChlVPP). Complete remission rates were 73% for previously untreated patients, 910% for patients previously treated with radiotherapy and 55%0 for patients previously treated with chemotherapy. In 59 patients with advanced disease who received no othe...

Minimum Fuel Trajectory in a 3/ D Time Scheduled Climb

Investigation of 3-D Flow in a Chamber

Investigation of 3-D Flow in a Chamber

AKT mediates actinomycin D-induced p53 expression

At high cytotoxic concentrations, actinomycin D (ActD) blocks transcription, decreasing levels of MDM2 and thus causing p53 stabilization. At low cytostatic concentrations, ActD causes ribosomal stress, which decreases MDM2 activity, resulting in p53 stabilization and activation. ActD can thus be used for p53-based cyclotherapy. We analyzed pathways mediating ActD-induced p53 expression. Inhibi...